IHydroxypropyl Methylcellulose (HPMC) yipolymer eguquguqukayo esetyenziswa ngokubanzi kumashishini ahlukeneyo, kubandakanya amayeza, ukutya, izinto zokuthambisa, kunye nokwakha.Iipropati zayo ezizodwa ziyenza ibe ngumgqatswa ogqwesileyo kwizicelo ezinjengokukhutshwa kweziyobisi ezilawulwayo, ii-agent ezityebisayo, ukugquma ifilimu, kunye nezinto zokwakha.Kweli nqaku, siza kuphonononga indlela yokupheliswa kwe-HPMC, sijonge ukubaluleka kwayo, ubuchule kunye nokusetyenziswa kwayo.Ukuqonda indlela yokupheliswa kwe-HPMC kubalulekile ekwandiseni ukusebenza kwayo kunye nokuphumeza iziphumo ezinqwenelekayo kwiinkalo ezahlukeneyo.
Ukubaluleka kokupheliswa kwe-HPMC
Ukupheliswa kwe-HPMC kubhekiselele kwinkqubo yokusasaza kunye nokunyibilikisa ipholima kulwelo oluphakathi.Eli nyathelo libaluleke kakhulu njengoko limisela izinga lokukhululwa, i-bioavailability, kunye nokusebenza kweemveliso ezisekelwe kwi-HPMC.Ukuziphatha kokuchithwa kwe-HPMC kuxhomekeke kwizinto ezahlukeneyo, kuquka ibakala le-HPMC, ubungakanani bamasuntswana, ubushushu, i-pH, kunye nobume bendawo ephakathi.Ngokufunda indlela yokuphelisa, abaphandi kunye nabavelisi banokuvavanya ukunyibilika, ukukhulula i-kinetics, kunye nokusebenza iyonke yokwenziwa kwe-HPMC, okukhokelela kuphuhliso oluphuculweyo lwemveliso kunye nokwenza ngcono.
Ubuchwephesha bokupheliswa kwe-HPMC
Iindlela ezininzi zisetyenziselwe ukufunda indlela yokuziphatha yokupheliswa kwe-HPMC.Iindlela ezisetyenziswa kakhulu ziquka:
a.I-Apparatus I (Isixhobo seBhaskithi): Le ndlela ibandakanya ukubeka isampulu ye-HPMC kwibhaskithi yomnatha, ethi ke intywiliselwe kwindawo yonyibiliko ngelixa ishukunyiswa.Le ndlela yobugcisa isoloko isetyenziselwa ukukhutshwa ngokukhawuleza kwaye inika ulwazi oluxabisekileyo malunga nesantya sokuchithwa kunye neprofayili yokukhululwa kwe-HPMC.
b.I-Apparatus II (i-Paddle apparatus): Kule ndlela, isampuli ifakwe kwisitya sokuchithwa, kwaye i-paddle isetyenziselwa ukuphazamisa i-medium.Obu buchwephesha bufanelekile kuzo zombini ukukhutshwa kwangoko kunye nokukhutshwa okwandisiweyo kwimixube, ukubonelela ngengqiqo kwizinga lokuchithwa kunye nokukhululwa kwe-kinetics ye-HPMC.
c.I-Apparatus III (i-Reciprocating cylinder apparatus): Obu buchule bubandakanya ukubeka isampuli kwi-cylinder ephindaphindayo, ehamba ngasemva naphambili kwi-medium dissolution.Le ndlela iqhele ukusetyenziselwa ukufunda imixube ye-HPMC-based based-release-release formulations kwaye inika ulwazi malunga nereyithi yokukhululwa kunye nokuziphatha kokusasazwa kweziyobisi.
d.I-Apparatus IV (I-Flow-through cell apparatus): Le ndlela isetyenziselwa ukufundisisa amabala okanye iinwebu ezisekelwe kwi-HPMC.Isampulu ifakwe phakathi kwamacandelo amabini, kwaye i-medium dissolution ivumelekile ukuba ihambe ngesampuli, ilinganisa ukukhutshwa kweziyobisi kwi-membrane.
Usetyenziso lwendlela yokupheliswa kwe-HPMC
Indlela yokupheliswa kwe-HPMC ifumana izicelo ezibanzi kumashishini ahlukeneyo:
a.Umzi-mveliso wamachiza: I-HPMC isetyenziswa ngokubanzi njengepolima ye-matrix yokulawulwa kokukhutshwa kweyeza.Indlela yokuphelisa inceda ekumiseleni inqanaba lokukhululwa, ukuziphatha kokusasazwa kweziyobisi, kunye nendlela yokukhupha iipilisi ezisekwe kwi-HPMC, iicapsules, kunye neepellets.Olu lwazi lubalulekile ekwandiseni ukuhanjiswa kweziyobisi kunye nokuqinisekisa ngeziphumo zonyango ezingaguqukiyo nezinokuqikelelwa kwangaphambili.
b.Ishishini lokutya: I-HPMC isetyenziswa njenge-arhente etyebisayo kunye nokuzinzisa kwiimveliso zokutya ezifana neesosi, iilokhwe, kunye neziselo.Indlela yokuchithwa inceda ekuqondeni iimpawu ze-hydration kunye ne-solubility ye-HPMC kwiimatriki zokutya ezahlukeneyo, igalelo ekuphuculeni ukuthungwa, ukuzinza, kunye neempawu zoluvo lweemveliso zokugqibela.
c.Imboni yezithambiso: I-HPMC iqeshwe kwizinto zokuthambisa kunye neemveliso zokunyamekela komntu njenge-agent-forming agent, i-emulsion stabilizer, kunye ne-viscosity modifier.Indlela yokuphelisa inceda ukuvavanya ukunyibilika kunye neempawu zokwenza ifilimu ye-HPMC, iqinisekisa ukuthungwa kwemveliso efunwayo, ukusasazeka, kunye nokuzinza kobomi beshelufu.
